Thursday, October 23, 2014

Jazmean's Phylogenetic Analysis Article

Jazmean Williams
AP Biology
Phylogenetic Analysis

How Closely Related are Dogs to Humans?

The basis of this Phylogenetic Analysis revolves around the domestication of dogs (Canis lupus familiaris) by humans (Homo sapiens). While there is no clear date as to when dogs were domesticated by humans, scientists know that dogs have been domesticated for a long time. Scientists also know that early human hunter-gatherers used dogs to perform many roles such as hunting, herding, and providing protection. This leads to the conclusion that humans domesticated dogs in order to improve their style of living. But why dogs? Why not choose another animal to domesticate? The answer lies within the idea of companionship. Dogs are known today as being man's best friend, however, becoming someone's best friend takes time and an immense amount of effort. Could it be that early humans were willing to put forth the effort in order to find another species they could relate to besides their own? Could the domestication of dogs begun with the intention of companionship instead of the completion of menial labor and protection?
To figure this out, three genes that exist in both dogs and humans will be analyzed and compared on a Phylogenetic Tree to see how closely related dogs and humans are. The closer in relation the dog and human are in the tree, the more alike they are, and the more likely they are to develop a bond with each other. The three genes that will analyzed are the PHOX2A gene, the TGIF1 gene, and the PROP1 gene. The PHOX2A gene deals with the development of the nervous system which affect bodily functions such as heart rate and breathing. The TGIF1 gene provides instructions to develop the front part of the brain. The PROP1 gene helps the pituitary gland release hormones that aid in growth and reproduction (along with other bodily functions). If the nervous system and front part of the brain develop in a similar fashion , then one an infer that there will be similar bodily and brain functions between the human and the dog. This applies too if the human and the dog grow and reproduce in a similar fashion. Also, in the tree, an outlying animal (the Zebrafish) will also be used to further help compare the dog with the human on the tree.
After doing the Phylogenetic Tree for each gene, it shows that the dog and the human share a recent common ancestor. Because both the dog and human share a more recent common ancestor, they share common structures and even patterns of behavior. All three animals share a common ancestor, but it is the dog and human that is most closely related due to both species having a more recent common ancestor with each other.
The results and inferences of this Phylogenetic Tree Analysis is similar to the information presented in scholarly articles. In the National Geographic, Jane J. Lee wrote an article about how the dog and human genomes evolved together in parallel evolution. Weiwei Zhai, a genetics researcher Lee references in their article, used genes that helped in the transport of neurotransmitters and cholesterol processing to compare the two species. He found that those genes were selected for in both humans and dogs. Zhai also found that there are cancer-related genes that are evolving together in humans and dogs. Weiwei Zhai believes this parallel evolution occurred due to the fact that dogs and humans lived closely together in the same environment. There is still debate however on whether the parallel evolution between humans and dogs are unique or if they exist in other domesticated animals as well.
The Huffington Post also reported an article about how dog brains process voices and emotions like humans which further supports the idea of humans and dogs being alike. Attila Andics, the researcher cited in this article, proposes that voice recognition between humans and dogs can explain why communication between the two species is so successful. He also proposes that this discovery can lead to an explanation of the “unique bond” humans and dogs have together.

The evidence provided from the Phylogenetic Tree and from the researchers aforementioned can solidify the possibility that dogs were domesticated with the intention of companionship and not labor. The companionship between the dog and the human could then lead off to a symbiotic relationship between the two species which is shown to have happened due to present day conditions. This way of thinking supports the idea that two species that live in the same environment will not always result to competition, but can work together to form a relationship that benefits the both of them.



Primary Sources for Discussion

Gene Sequences Used

Software Used

5 comments:

  1. Your comparison of humans to dogs I found very interesting especially after reading about how humans and dogs come from a common species. Do you happen to know what the common species is? Also, the fact that humans and dogs evolved together in a parallel evolution is very interesting. Have you found research on other genes, besides the cancer related gene, that evolved with humans and dogs relatively at the same time?

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    1. The common species for dogs and humans is not known because the mammalian lineage is still being worked out. But scientists predict that the common ancestor for dogs and humans had a brain the size of an egg.

      I would have to find more information if there are more genes that evolved relatively the same time but I would infer that there would be more due to the fact that dogs and humans lived in close environments for a long period of time.

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  2. Overall, this article is very interesting and well-worded. When you were preparing a question for this article, did you think of using any other domesticated animals for the comparison? For example, a cat could also be an interesting animal to research about in comparison to a human.

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    1. Thank you! And to be honest, I didn't think of any other animal to try. Dogs were the animals I chose because of the long history they had with humans. But cats would be great species to try to see if there's a pattern.

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  3. Overall I found your article to be extremely interesting. I loved how you discussed and compared the original purpose for domesticating dogs to whether it was for companionship or labor. In order to solidify your results, choosing three genes to compare was extremely beneficial for your article. One question I would have is, are there any other animal species that has a companionship with humans that would not be so similar to humans at first glance but genetically they are? Maybe this could be used as a basis for further research.

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